CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.70 | Cathepsin D, subunit A; domain 1 | |
2.40.70.10 | Acid Proteases |
Domain Context
CATH Clusters
Superfamily | Acid Proteases |
Functional Family | Pepsin A |
Enzyme Information
3.4.23.3 |
Gastricsin.
based on mapping to UniProt P20142
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.
-!- Formed from progastricsin, apparently in the gastric juice of most vertebrates. -!- In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. -!- Seminal plasma contains a zymogen that is immunologically identical with progastricsin. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.22.
|
UniProtKB Entries (1)
P20142 |
PEPC_HUMAN
Homo sapiens
Gastricsin
|
PDB Structure
PDB | 1HTR |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal and molecular structures of human progastricsin at 1.62 A resolution.
J.Mol.Biol.
|