CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.10 | Roll | |
3.10.20 | Ubiquitin-like (UB roll) | |
3.10.20.70 | Glutamine synthetase, N-terminal domain |
Domain Context
CATH Clusters
Superfamily | Glutamine synthetase, N-terminal domain |
Functional Family | Glutamine synthetase |
Enzyme Information
6.3.1.2 |
Glutamine synthetase.
based on mapping to UniProt P9WN39
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.
-!- Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. -!- Several types have been described, differing in their oligomeric structures and cofactor requirements.
|
UniProtKB Entries (1)
P9WN39 |
GLN1B_MYCTU
Mycobacterium tuberculosis H37Rv
Glutamine synthetase
|
PDB Structure
PDB | 1HTQ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation.
Biochemistry
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