CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.1060 | Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2 | |
1.10.1060.10 | Alpha-helical ferredoxin |
Domain Context
CATH Clusters
Superfamily | Alpha-helical ferredoxin |
Functional Family | Dihydropyrimidine dehydrogenase [NADP(+)] |
Enzyme Information
1.3.1.2 |
Dihydropyrimidine dehydrogenase (NADP(+)).
based on mapping to UniProt Q28943
5,6-dihydrouracil + NADP(+) = uracil + NADPH.
-!- Also acts on dihydrothymine.
|
UniProtKB Entries (1)
Q28943 |
DPYD_PIG
Sus scrofa
Dihydropyrimidine dehydrogenase [NADP(+)]
|
PDB Structure
PDB | 1H7X |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal Structure of Dihydropyrimidine Dehydrogenase, a Major Determinant of the Pharmacokinetics of the Anti-Cancer Drug 5-Fluorouracil
Embo J.
|