CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.50 | Alpha/alpha barrel |
|
1.50.10 | Glycosyltransferase |
|
1.50.10.20 |
Domain Context
CATH Clusters
| Superfamily | 1.50.10.20 |
| Functional Family |
Enzyme Information
| 5.4.99.17 |
Squalene--hopene cyclase.
based on mapping to UniProt P33247
Squalene = hop-22(29)-ene.
-!- The enzyme also produces the cyclization product hopan-22-ol by addition of water (cf. EC 4.2.1.129). -!- Hopene and hopanol are formed at a constant ratio of 5:1.
|
| 4.2.1.129 |
Squalene--hopanol cyclase.
based on mapping to UniProt P33247
Hopan-22-ol = squalene + H(2)O.
-!- The enzyme produces the cyclization products hopene (cf. EC 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1.
|
UniProtKB Entries (1)
| P33247 |
SQHC_ALIAD
Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446
Squalene--hopene cyclase
|
PDB Structure
| PDB | 1H3A |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem.
|