CATH Domain 1g83A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.30	SH3 type barrels.
	2.30.30.40	SH3 Domains

Domain Context

CATH Clusters

Superfamily	SH3 Domains
Functional Family	Tyrosine-protein kinase Fyn

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P06241

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06241

FYN_HUMAN

Homo sapiens

Tyrosine-protein kinase Fyn

PDB Structure

PDB	1G83
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases. Arold, S.T., Ulmer, T.S., Mulhern, T.D., Werner, J.M., Ladbury, J.E., Campbell, I.D., Noble, M.E. J.Biol.Chem.