CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate/ornithine carbamoyltransferase
Functional Family Ornithine carbamoyltransferase, mitochondrial

Enzyme Information

2.1.3.3
Ornithine carbamoyltransferase.
based on mapping to UniProt P00480
Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.
-!- The plant enzyme also catalyzes the reactions of EC 2.1.3.6, EC 2.7.2.2 and EC 3.5.3.12, thus acting as putrescine synthase, converting agmatine and ornithine into putrescine and citrulline respectively.

UniProtKB Entries (1)

P00480
OTC_HUMAN
Homo sapiens
Ornithine carbamoyltransferase, mitochondrial

PDB Structure

PDB 1FVO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes.
Shi, D., Morizono, H., Yu, X., Tong, L., Allewell, N.M., Tuchman, M.
Biochem.J.