CATH Classification

Domain Context

CATH Clusters

Superfamily 2.60.120.200
Functional Family Tetanus toxin

Enzyme Information

3.4.24.68
Tentoxilysin.
based on mapping to UniProt P04958
Hydrolysis of 76-Gln-|-Phe-77 bond in synaptobrevin 2.
-!- Belongs to peptidase family M27.

UniProtKB Entries (1)

P04958
TETX_CLOTE
Clostridium tetani E88
Tetanus toxin

PDB Structure

PDB 1FV3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin.
Fotinou, C., Emsley, P., Black, I., Ando, H., Ishida, H., Kiso, M., Sinha, K.A., Fairweather, N.F., Isaacs, N.W.
J.Biol.Chem.