CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1360 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1360 |
| Functional Family | Glucosamine-6-phosphate deaminase |
Enzyme Information
| 3.5.99.6 |
Glucosamine-6-phosphate deaminase.
based on mapping to UniProt P0A759
Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).
-!- Isomerization of the aldose-ketose type converts the -CH(-NH(2))-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH(2)-OH, forming 2-deoxy-2-imino-D-arabino-hexitol which then hydrolyzes to yield fructose 6-phosphate and ammonia. -!- N-acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme. -!- Formerly EC 5.3.1.10.
|
UniProtKB Entries (1)
| P0A759 |
NAGB_ECOLI
Escherichia coli K-12
Glucosamine-6-phosphate deaminase
|
PDB Structure
| PDB | 1FS6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural flexibility, an essential component of the allosteric activation in Escherichia coli glucosamine-6-phosphate deaminase.
Acta Crystallogr.,Sect.D
|
