CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.5 | Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
|
1.20.5.460 | Single helix bin |
Domain Context
CATH Clusters
| Superfamily | Single helix bin |
| Functional Family | Formate dehydrogenase subunit alpha |
Enzyme Information
| 1.17.1.9 |
Formate dehydrogenase.
based on mapping to UniProt P07658
Formate + NAD(+) = CO(2) + NADH.
-!- The enzyme from most aerobic organisms is devoid of redox-active centers but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centers, flavin and a molybdenum center. -!- Together with EC 1.12.1.2, forms a system previously known as formate hydrogenlyase. -!- Formerly EC 1.2.1.2.
|
| 1.17.99.7 |
Formate dehydrogenase (acceptor).
based on mapping to UniProt P07658
Formate + acceptor = CO(2) + reduced acceptor.
-!- Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. -!- The two enzymes form the formate-hydrogen lyase complex. -!- The enzyme contains a selenocysteine residue. -!- Formerly EC 1.1.99.33.
|
UniProtKB Entries (1)
| P07658 |
FDHF_ECOLI
Escherichia coli K-12
Formate dehydrogenase H
|
PDB Structure
| PDB | 1FDO |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster.
Science
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