CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family |
Enzyme Information
| 3.4.21.21 |
Coagulation factor VIIa.
based on mapping to UniProt P08709
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (2)
| P00974 |
BPT1_BOVIN
Bos taurus
Pancreatic trypsin inhibitor
|
| P13726 |
TF_HUMAN
Homo sapiens
Tissue factor
|
PDB Structure
| PDB | 1FAK |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Cricetulus |
| Primary Citation |
Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.
J.Mol.Biol.
|
