CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.60 | 4-Layer Sandwich | |
3.60.110 | Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase | |
3.60.110.10 | Carbon-nitrogen hydrolase |
Domain Context
CATH Clusters
Superfamily | Carbon-nitrogen hydrolase |
Functional Family | N-carbamoyl-D-amino acid hydrolase |
Enzyme Information
3.5.1.77 |
N-carbamoyl-D-amino-acid hydrolase.
based on mapping to UniProt P60327
N-carbamoyl-D-amino acid + H(2)O = D-amino acid + NH(3) + CO(2).
-!- This enzyme, along with EC 3.5.1.87, EC 5.1.99.5 and EC 3.5.2.2, forms part of the reaction cascade known as the 'hydantoinase process', which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids. -!- Has strict stereospecificity for N-carbamoyl-D-amino acids and does not act upon the corresponding L-amino acids or N-formyl amino acids, N-carbamoyl-sarcosine, -citrulline, -allantoin and -ureidopropanoate, which are substrates for other amidohydrolases.
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UniProtKB Entries (1)
P60327 |
DCAS_AGRSK
Agrobacterium sp. KNK712
N-carbamoyl-D-amino acid hydrolase
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PDB Structure
PDB | 1ERZ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structure of N-carbamyl-D-amino acid amidohydrolase with a novel catalytic framework common to amidohydrolases.
Structure Fold.Des.
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