CATH Domain 1eonA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.600	ECO RV Endonuclease; Chain A
	3.40.600.10	DNA mismatch repair MutH/Restriction endonuclease, type II

Domain Context

CATH Clusters

Superfamily	DNA mismatch repair MutH/Restriction endonuclease, type II
Functional Family

Enzyme Information

3.1.21.4

Type II site-specific deoxyribonuclease.

based on mapping to UniProt P04390

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

-!- Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P04390

T2E5_ECOLX

Escherichia coli

Type-2 restriction enzyme EcoRV

PDB Structure

PDB	1EON
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study Horton, N.C., Connolly, B.A., Perona, J.J. J.Am.Chem.Soc.