CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Outer capsid protein lambda-2

Enzyme Information

2.7.7.50
mRNA guanylyltransferase.
based on mapping to UniProt P11079
GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.
-!- Can modify also synthetic poly(A) and poly(G) to form the structures m(7)G(5')pppAn and m(7)G(5')pppGn.
2.1.1.56
mRNA (guanine-N(7)-)-methyltransferase.
based on mapping to UniProt P11079
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
-!- Adds an N(7)-methylguanine cap to mRNA. -!- The nucleoside next to the terminal guanosine may be either guanosine or adenosine.

UniProtKB Entries (2)

P15024
LMBD1_REOVD
Mammalian orthoreovirus 3 Dearing
Inner capsid protein lambda-1
P11314
SIGM2_REOVL
Mammalian orthoreovirus 1 Lang
Inner capsid protein sigma-2

PDB Structure

PDB 1EJ6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the reovirus core at 3.6 A resolution.
Reinisch, K.M., Nibert, M.L., Harrison, S.C.
Nature