CATH Domain 1e8cA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1390	Udp-n-acetylmuramoylalanyl-d-glutamate--2,6- Diaminopimelate Ligase; Chain: A, domain 1
	3.40.1390.10	MurE/MurF, N-terminal domain

Domain Context

CATH Clusters

Superfamily	MurE/MurF, N-terminal domain
Functional Family	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

Enzyme Information

6.3.2.13

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase.

based on mapping to UniProt P22188

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6- diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate.

-!- Involved in the synthesis of a cell-wall peptide. -!- This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC 6.3.2.7 adds lysine instead. -!- It is the amino group of the L-center of the diaminopimelate that is acylated.

UniProtKB Entries (1)

P22188

MURE_ECOLI

Escherichia coli K-12

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

PDB Structure

PDB	1E8C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Udp-N-Acetylmuramoyl-L-Alanyl-D-Glutamate: Meso-Diaminopimelate Ligase from Escherichia Coli Gordon, E.J., Flouret, B., Chantalat, L., Van Heijenoort, J., Mengin-Lecreulx, D., Dideberg, O. J.Biol.Chem.