CATH Classification

Domain Context

CATH Clusters

Superfamily HRDC domain
Functional Family ATP-dependent helicase SGS1

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P35187
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P35187
SGS1_YEAST
Saccharomyces cerevisiae S288C
ATP-dependent helicase SGS1

PDB Structure

PDB 1D8B
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
Liu, Z., Macias, M.J., Bottomley, M.J., Stier, G., Linge, J.P., Nilges, M., Bork, P., Sattler, M.
Structure Fold.Des.