CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family Antiviral protein I

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P10297
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P10297
RIP1_PHYAM
Phytolacca americana
Antiviral protein I

PDB Structure

PDB 1D6A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray crystallographic analysis of the structural basis for the interaction of pokeweed antiviral protein with guanine residues of ribosomal RNA.
Kurinov, I.V., Rajamohan, F., Venkatachalam, T.K., Uckun, F.M.
Protein Sci.