CATH Classification
Level | CATH Code | Description |
---|---|---|
4 | Few Secondary Structures | |
4.10 | Irregular | |
4.10.470 | Ricin (A Subunit), domain 2 | |
4.10.470.10 | Ricin (A Subunit), domain 2 |
Domain Context
CATH Clusters
Superfamily | Ricin (A Subunit), domain 2 |
Functional Family | Antiviral protein I |
Enzyme Information
3.2.2.22 |
rRNA N-glycosylase.
based on mapping to UniProt P10297
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.
|
UniProtKB Entries (1)
P10297 |
RIP1_PHYAM
Phytolacca americana
Antiviral protein I
|
PDB Structure
PDB | 1D6A |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
X-ray crystallographic analysis of the structural basis for the interaction of pokeweed antiviral protein with guanine residues of ribosomal RNA.
Protein Sci.
|