CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.46 | Glycine N-methyltransferase; chain A, domain 1 |
|
3.30.46.10 | Glycine N-methyltransferase, chain A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Glycine N-methyltransferase, chain A, domain 1 |
| Functional Family | Glycine N-methyltransferase |
Enzyme Information
| 2.1.1.20 |
Glycine N-methyltransferase.
based on mapping to UniProt P13255
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.
-!- Thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. -!- Inhibited by 5-methyltetrahydrofolate pentaglutamate. -!- Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3.
|
UniProtKB Entries (1)
| P13255 |
GNMT_RAT
Rattus norvegicus
Glycine N-methyltransferase
|
PDB Structure
| PDB | 1D2C |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol.
|