CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.367 | Hexokinase; domain 1 |
|
3.40.367.20 |
Domain Context
CATH Clusters
| Superfamily | 3.40.367.20 |
| Functional Family | Hexokinase 1 |
Enzyme Information
| 2.7.1.1 |
Hexokinase.
based on mapping to UniProt P19367
ATP + D-hexose = ADP + D-hexose 6-phosphate.
-!- D-glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors. -!- ITP and dATP can act as donors.
|
UniProtKB Entries (1)
| P19367 |
HXK1_HUMAN
Homo sapiens
Hexokinase-1
|
PDB Structure
| PDB | 1CZA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
J.Mol.Biol.
|
