CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.640 | Aspartate Aminotransferase; domain 2 |
|
3.40.640.10 | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
Domain Context
CATH Clusters
| Superfamily | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
| Functional Family | Cystathionine gamma-synthase |
Enzyme Information
| 2.5.1.48 |
Cystathionine gamma-synthase.
based on mapping to UniProt P00935
O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate.
-!- Also reacts with H(2)S and methanethiol as replacing agents, producing homocysteine and methionine, respectively. -!- In the absence of thiol, can also catalyze beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia. -!- Formerly EC 4.2.99.9.
|
UniProtKB Entries (1)
| P00935 |
METB_ECOLI
Escherichia coli K-12
Cystathionine gamma-synthase
|
PDB Structure
| PDB | 1CS1 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution.
EMBO J.
|