CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.360 |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.360 |
| Functional Family |
Enzyme Information
| 3.4.17.11 |
Glutamate carboxypeptidase.
based on mapping to UniProt P06621
Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups.
-!- Produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp. -!- Its ability to hydrolyze pteroyl-L-glutamate (folic acid) has led to its use as a folate-depleting, antitumor agent. -!- Belongs to peptidase family M20A.
|
UniProtKB Entries (1)
| P06621 |
CBPG_PSES6
Pseudomonas sp. RS-16
Carboxypeptidase G2
|
PDB Structure
| PDB | 1CG2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy.
Structure
|
