CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.680 | Activated P21cdc42hs Kinase; Chain B |
|
4.10.680.10 | Cdc42-like binding domain |
Domain Context
CATH Clusters
| Superfamily | Cdc42-like binding domain |
| Functional Family | activated CDC42 kinase 1 isoform X1 |
Enzyme Information
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q07912
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
| 2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q07912
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| Q07912 |
ACK1_HUMAN
Homo sapiens
Activated CDC42 kinase 1
|
PDB Structure
| PDB | 1CF4 |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.
Nature
|
