CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.10 | Roll | |
3.10.110 | Ubiquitin Conjugating Enzyme | |
3.10.110.10 | Ubiquitin Conjugating Enzyme |
Domain Context
CATH Clusters
Superfamily | Ubiquitin Conjugating Enzyme |
Functional Family | Ubiquitin-conjugating enzyme E2 L3 |
Enzyme Information
2.3.2.23 |
E2 ubiquitin-conjugating enzyme.
based on mapping to UniProt P68036
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L- cysteine.
-!- The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. -!- In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage. -!- Formerly EC 6.3.2.19.
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UniProtKB Entries (1)
Q05086 |
UBE3A_HUMAN
Homo sapiens
Ubiquitin-protein ligase E3A
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PDB Structure
PDB | 1C4Z |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
Science
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