CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarase/aspartase (C-terminal domain)
Functional Family Adenylosuccinate lyase

Enzyme Information

4.3.2.2
Adenylosuccinate lyase.
based on mapping to UniProt Q9X0I0
(1) N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP. (2) (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
-!- Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5- aminoimidazole.

UniProtKB Entries (1)

Q9X0I0
PUR8_THEMA
Thermotoga maritima MSB8
Adenylosuccinate lyase

PDB Structure

PDB 1C3U
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway.
Toth, E.A., Yeates, T.O.
Structure Fold.Des.