CATH Domain 1bp4A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Papain

Enzyme Information

3.4.22.2

Papain.

based on mapping to UniProt P00784

Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.

-!- From latex of the papaya (Carica papaya). -!- Inhibited by compound E-64 and proteins of the cystatin family. -!- Belongs to peptidase family C1. -!- Formerly EC 3.4.4.10.

UniProtKB Entries (1)

P00784

PAPA1_CARPA

Carica papaya

Papain

PDB Structure

PDB	1BP4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites. LaLonde, J.M., Zhao, B., Smith, W.W., Janson, C.A., DesJarlais, R.L., Tomaszek, T.A., Carr, T.J., Thompson, S.K., Oh, H.J., Yamashita, D.S., Veber, D.F., Abdel-Meguid, S.S. J.Med.Chem.