CATH Classification
Level | CATH Code | Description |
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2 | Mainly Beta |
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2.60 | Sandwich |
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2.60.120 | Jelly Rolls |
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2.60.120.330 | B-lactam Antibiotic, Isopenicillin N Synthase; Chain |
Domain Context
CATH Clusters
Superfamily | B-lactam Antibiotic, Isopenicillin N Synthase; Chain |
Functional Family | Isopenicillin N synthase |
Enzyme Information
1.21.3.1 |
Isopenicillin-N synthase.
based on mapping to UniProt P05326
N-((5S)-5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + O(2) = isopenicillin N + 2 H(2)O.
-!- Forms part of the penicillin biosynthesis pathway.
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UniProtKB Entries (1)
P05326 |
IPNS_EMENI
Aspergillus nidulans FGSC A4
Isopenicillin N synthase
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PDB Structure
PDB | 1BLZ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
Nature
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