CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.199 | Topoisomerase II; domain 5 |
|
3.90.199.10 | Topoisomerase II, domain 5 |
Domain Context
CATH Clusters
| Superfamily | Topoisomerase II, domain 5 |
| Functional Family | DNA topoisomerase 2 |
Enzyme Information
| 5.6.2.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P06786
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
|
UniProtKB Entries (1)
| P06786 |
TOP2_YEAST
Saccharomyces cerevisiae S288C
DNA topoisomerase 2
|
PDB Structure
| PDB | 1BJT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Saccharomyces |
| Primary Citation |
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands.
Nat.Struct.Biol.
|
