CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA polymerase I

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P19821
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P19821
DPO1_THEAQ
Thermus aquaticus
DNA polymerase I, thermostable

PDB Structure

PDB 1BGX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Taq DNA polymerase in complex with an inhibitory Fab: the Fab is directed against an intermediate in the helix-coil dynamics of the enzyme.
Murali, R., Sharkey, D.J., Daiss, J.L., Murthy, H.M.
Proc.Natl.Acad.Sci.USA