CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.600 | ECO RV Endonuclease; Chain A |
|
3.40.600.10 | DNA mismatch repair MutH/Restriction endonuclease, type II |
Domain Context
CATH Clusters
| Superfamily | DNA mismatch repair MutH/Restriction endonuclease, type II |
| Functional Family |
Enzyme Information
| 3.1.21.4 |
Type II site-specific deoxyribonuclease.
based on mapping to UniProt P04390
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.
-!- Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
|
UniProtKB Entries (1)
| P04390 |
T2E5_ECOLX
Escherichia coli
Type-2 restriction enzyme EcoRV
|
PDB Structure
| PDB | 1B95 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural analysis of a mutational hot-spot in the EcoRV restriction endonuclease: a catalytic role for a main chain carbonyl group.
Nucleic Acids Res.
|
