CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Kallikrein 1-related peptidase C9 |
Enzyme Information
| 3.4.21.119 |
Kallikrein 13.
based on mapping to UniProt P36368
Hydrolyzes mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-|- pair in the N-terminus, to yield mature renin.
-!- Specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates. -!- Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used. -!- Also able to process pro-interleukin-1-beta (pro-IL-1-beta) in mouse submandibular gland to form IL-1-beta. -!- Belongs to peptidase family S1A.
|
UniProtKB Entries (1)
| P36368 |
EGFB2_MOUSE
Mus musculus
Epidermal growth factor-binding protein type B
|
PDB Structure
| PDB | 1AO5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The crystal structure of the mouse glandular kallikrein-13 (prorenin converting enzyme)
Protein Sci.
|
