CATH Classification

Domain Context

CATH Clusters

Superfamily Serralysin-like metalloprotease, C-terminal
Functional Family Serralysin

Enzyme Information

3.4.24.40
Serralysin.
based on mapping to UniProt Q03023
Preferential cleavage of bonds with hydrophobic residues in P1'.
-!- An extracellular endopeptidase from Pseudomonas aeruginosa, Escherichia freundii, Serratia marcescens and Erwinia chrysanthemi. -!- There is broad specificity in cleavage of the insulin B chain, with some species variations. -!- The pH optimum for digesting various proteins is about 9-10. -!- Belongs to peptidase family M10A. -!- Formerly EC 3.4.24.4.

UniProtKB Entries (1)

Q03023
APRA_PSEAE
Pseudomonas aeruginosa PAO1
Serralysin

PDB Structure

PDB 1AKL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the unliganded alkaline protease from Pseudomonas aeruginosa IFO3080 and its conformational changes on ligand binding.
Miyatake, H., Hata, Y., Fujii, T., Hamada, K., Morihara, K., Katsube, Y.
J.Biochem.(Tokyo)
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