CATH Domain 1ad4A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.20	Dihydropteroate synthase-like

Domain Context

CATH Clusters

Superfamily	Dihydropteroate synthase-like
Functional Family	Dihydropteroate synthase

Enzyme Information

2.5.1.15

Dihydropteroate synthase.

based on mapping to UniProt O05701

6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

-!- The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). -!- The enzyme exists in varying types of multifunctional proteins in different organisms. -!- The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25.

UniProtKB Entries (1)

O05701

DHPS_STAAU

Staphylococcus aureus

Dihydropteroate synthase

PDB Structure

PDB	1AD4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and function of the dihydropteroate synthase from Staphylococcus aureus. Hampele, I.C., D'Arcy, A., Dale, G.E., Kostrewa, D., Nielsen, J., Oefner, C., Page, M.G., Schonfeld, H.J., Stuber, D., Then, R.L. J.Mol.Biol.