CATH Domain 1a4gA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.120	6 Propeller
	2.120.10	Neuraminidase
	2.120.10.10

Domain Context

CATH Clusters

Superfamily	2.120.10.10
Functional Family

Enzyme Information

3.2.1.18

Exo-alpha-sialidase.

based on mapping to UniProt P27907

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P27907

NRAM_INBBE

Influenza B virus (STRAIN B/BEIJING/1/87)

Neuraminidase

PDB Structure

PDB	1A4G
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B. Taylor, N.R., Cleasby, A., Singh, O., Skarzynski, T., Wonacott, A.J., Smith, P.W., Sollis, S.L., Howes, P.D., Cherry, P.C., Bethell, R., Colman, P., Varghese, J. J.Med.Chem.