CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) |
|
1.20.120.380 | Type 1-topoisomerase catalytic fragment, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Type 1-topoisomerase catalytic fragment, domain 2 |
| Functional Family |
Enzyme Information
| 5.6.2.2 |
DNA topoisomerase.
based on mapping to UniProt P68698
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.
|
UniProtKB Entries (1)
| P68698 |
TOP1_VACCW
Vaccinia virus WR
DNA topoisomerase 1B
|
PDB Structure
| PDB | 1A41 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases.
Cell(Cambridge,Mass.)
|
