CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Estradiol 17-beta-dehydrogenase 1

Enzyme Information
17-beta-estradiol 17-dehydrogenase.
based on mapping to UniProt P14061
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
-!- The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids. -!- The mammalian enzyme is bifunctional and also catalyzes EC -!- The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC, it is Si-specific with respect to NAD(P)(+).

UniProtKB Entries (1)

Homo sapiens
Estradiol 17-beta-dehydrogenase 1

PDB Structure

PDB 1A27
External Links
Primary Citation
Human Type I 17Beta-Hydroxysteroid Dehydrogenase: Site Directed Mutagenesis and X-Ray Crystallography Structure-Function Analysis
Mazza, C.
Thesis, Universite Joseph Fourier