The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Helix-loop-helix DNA-binding domain
".
FunFam 5822: Aryl hydrocarbon receptor 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 21 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
5 | A8JRD4 (/IPI) A8JRD5 (/IPI) Q2WGN8 (/IPI) Q8BGD7 (/IPI) Q9VBH3 (/IPI) |
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
|
4 | A8JRD4 (/ISS) A8JRD5 (/ISS) Q2WGN8 (/ISS) Q9VBH3 (/ISS) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
4 | A8JRD4 (/IDA) A8JRD5 (/IDA) Q2WGN8 (/IDA) Q9VBH3 (/IDA) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
4 | A8JRD4 (/TAS) A8JRD5 (/TAS) Q2WGN8 (/TAS) Q9VBH3 (/TAS) |
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
|
3 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) |
RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
|
3 | Q1LV27 (/IDA) Q8IUM7 (/IDA) Q9YGV3 (/IDA) |
RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
|
3 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | G5EFA5 (/IPI) G5EFL9 (/IPI) Q8IUM7 (/IPI) |
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
|
2 | Q8BGD7 (/IDA) Q8IUM7 (/IDA) |
Aryl hydrocarbon receptor activity GO:0004874
Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding.
|
2 | Q1LV27 (/IDA) Q9YGV3 (/IDA) |
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
|
2 | Q1LV27 (/IDA) Q9YGV3 (/IDA) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
2 | Q1LV27 (/IPI) Q9YGV3 (/IPI) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q8CJH6 (/IDA) Q8IUM7 (/IDA) |
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
|
1 | Q8BGD7 (/ISO) |
RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
|
1 | Q8BGD7 (/IMP) |
RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
|
1 | Q8BGD7 (/ISO) |
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
1 | Q8BGD7 (/IDA) |
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
|
1 | Q8IUM7 (/IDA) |
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
|
1 | Q8BGD7 (/ISO) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q8BGD7 (/IDA) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q8BGD7 (/ISO) |
There are 45 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
10 | A8JRD4 (/IDA) A8JRD5 (/IDA) G5EFA5 (/IDA) G5EFL9 (/IDA) Q1LV27 (/IDA) Q2WGN8 (/IDA) Q8BGD7 (/IDA) Q8IUM7 (/IDA) Q9VBH3 (/IDA) Q9YGV3 (/IDA) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | A8JRD4 (/ISS) A8JRD5 (/ISS) Q2WGN8 (/ISS) Q9VBH3 (/ISS) |
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
4 | A8JRD4 (/IDA) A8JRD5 (/IDA) Q2WGN8 (/IDA) Q9VBH3 (/IDA) |
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
4 | A8JRD4 (/IDA) A8JRD5 (/IDA) Q2WGN8 (/IDA) Q9VBH3 (/IDA) |
Epithelial cell migration, open tracheal system GO:0007427
The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster.
|
4 | A8JRD4 (/IMP) A8JRD5 (/IMP) Q2WGN8 (/IMP) Q9VBH3 (/IMP) |
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
|
4 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) Q8IUM7 (/ISS) |
Short-term memory GO:0007614
The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.
|
4 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) Q8IUM7 (/ISS) |
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
4 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) Q8IUM7 (/ISS) |
Imaginal disc-derived leg joint morphogenesis GO:0016348
The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster.
|
4 | A8JRD4 (/IMP) A8JRD5 (/IMP) Q2WGN8 (/IMP) Q9VBH3 (/IMP) |
Regulation of synaptic transmission, GABAergic GO:0032228
Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
|
4 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) Q8IUM7 (/ISS) |
Branch fusion, open tracheal system GO:0035147
Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint.
|
4 | A8JRD4 (/IEP) A8JRD5 (/IEP) Q2WGN8 (/IEP) Q9VBH3 (/IEP) |
Branch fusion, open tracheal system GO:0035147
Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint.
|
4 | A8JRD4 (/IMP) A8JRD5 (/IMP) Q2WGN8 (/IMP) Q9VBH3 (/IMP) |
Social behavior GO:0035176
Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
|
4 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) Q8IUM7 (/ISS) |
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
4 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) Q8IUM7 (/ISS) |
Excitatory postsynaptic potential GO:0060079
A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
|
4 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) Q8IUM7 (/ISS) |
Inhibitory postsynaptic potential GO:0060080
A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
|
4 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) Q8IUM7 (/ISS) |
Morphogenesis of an epithelial fold GO:0060571
The morphogenetic process in which an epithelial sheet bends along a linear axis.
|
4 | A8JRD4 (/IMP) A8JRD5 (/IMP) Q2WGN8 (/IMP) Q9VBH3 (/IMP) |
Inhibitory synapse assembly GO:1904862
The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse.
|
4 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) Q8IUM7 (/ISS) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) |
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | E7FFX1 (/ISS) Q1ECW2 (/ISS) Q8CJH6 (/ISS) |
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q1LV27 (/IMP) Q9YGV3 (/IMP) |
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
|
2 | Q1LV27 (/IDA) Q9YGV3 (/IDA) |
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
|
2 | Q1LV27 (/IMP) Q9YGV3 (/IMP) |
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
|
2 | Q1LV27 (/IPI) Q9YGV3 (/IPI) |
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
|
2 | Q1LV27 (/IMP) Q9YGV3 (/IMP) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q1LV27 (/IPI) Q9YGV3 (/IPI) |
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
2 | Q1LV27 (/IGI) Q9YGV3 (/IGI) |
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
2 | Q1LV27 (/IMP) Q9YGV3 (/IMP) |
Cellular response to xenobiotic stimulus GO:0071466
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
|
2 | Q1LV27 (/IDA) Q9YGV3 (/IDA) |
Cellular response to xenobiotic stimulus GO:0071466
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
|
2 | Q1LV27 (/IMP) Q9YGV3 (/IMP) |
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
|
1 | Q8BGD7 (/IMP) |
Short-term memory GO:0007614
The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.
|
1 | Q8BGD7 (/IMP) |
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
1 | Q8BGD7 (/IMP) |
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
|
1 | Q1ECW2 (/IMP) |
Regulation of synaptic transmission, GABAergic GO:0032228
Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
|
1 | Q8BGD7 (/IMP) |
Social behavior GO:0035176
Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
|
1 | Q8BGD7 (/IMP) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q8BGD7 (/IDA) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q8BGD7 (/IMP) |
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q8BGD7 (/IMP) |
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q8BGD7 (/ISO) |
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | Q8BGD7 (/IMP) |
Excitatory postsynaptic potential GO:0060079
A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
|
1 | Q8BGD7 (/IMP) |
Inhibitory postsynaptic potential GO:0060080
A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
|
1 | Q8BGD7 (/IMP) |
Cellular response to corticosterone stimulus GO:0071386
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.
|
1 | Q8BGD7 (/IDA) |
Inhibitory synapse assembly GO:1904862
The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse.
|
1 | Q8BGD7 (/IMP) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | A8JRD4 (/IDA) A8JRD5 (/IDA) Q1LV27 (/IDA) Q2WGN8 (/IDA) Q8BGD7 (/IDA) Q9VBH3 (/IDA) Q9YGV3 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | A8JRD4 (/IC) A8JRD5 (/IC) G5EFA5 (/IC) G5EFL9 (/IC) Q2WGN8 (/IC) Q9VBH3 (/IC) |
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
|
4 | A8JRD4 (/IPI) A8JRD5 (/IPI) Q2WGN8 (/IPI) Q9VBH3 (/IPI) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q1LV27 (/IDA) Q9YGV3 (/IDA) |
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II.
|
2 | G5EFA5 (/IDA) G5EFL9 (/IDA) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | Q8BGD7 (/IDA) |