The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5790: MYC transcription factor 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
27 F4KAJ5 (/ISS) O23090 (/ISS) O23487 (/ISS) O49687 (/ISS) O81900 (/ISS) Q0WNR2 (/ISS) Q1PF16 (/ISS) Q1PF17 (/ISS) Q39204 (/ISS) Q700E3 (/ISS)
(17 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 Q336P5 (/IPI) Q39204 (/IPI) Q6YUS3 (/IPI) Q9CAD0 (/IPI) Q9FIP9 (/IPI) Q9FN69 (/IPI) Q9FT81 (/IPI) Q9LSE2 (/IPI) Q9ZVX2 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 Q39204 (/IDA) Q9LSE2 (/IDA) Q9LUK7 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 O81900 (/IPI) Q1PF16 (/IPI) Q39204 (/IPI)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
2 O81900 (/IDA) Q9ZPY8 (/IDA)
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
2 O49687 (/IPI) Q9FIP9 (/IPI)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q9FT81 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q9FT81 (/IPI)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
1 Q9ZVX2 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q6YUS3 (/IMP)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q9LSE2 (/TAS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q9ZVX2 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 Q9LUK7 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q9LUK7 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q39204 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 Q9LNJ5 (/IPI)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
22 F4KAJ5 (/TAS) O23090 (/TAS) O23487 (/TAS) O49687 (/TAS) O81900 (/TAS) Q0WNR2 (/TAS) Q1PF16 (/TAS) Q1PF17 (/TAS) Q700E3 (/TAS) Q8S3F1 (/TAS)
(12 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 O49687 (/IDA) Q39204 (/IDA) Q9FIP9 (/IDA) Q9LSE2 (/IDA)
Jasmonic acid mediated signaling pathway GO:0009867
A series of molecular signals mediated by jasmonic acid.
3 Q9CAD0 (/IMP) Q9FN69 (/IMP) Q9FT81 (/IMP)
Trichome differentiation GO:0010026
The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana.
3 Q9CAD0 (/IMP) Q9FN69 (/IMP) Q9FT81 (/IMP)
Anther wall tapetum development GO:0048658
The process whose specific outcome is the progression of the anther wall tapetum over time, from its formation to the mature structure.
3 B9FXT3 (/IMP) O81900 (/IMP) Q9ZVX2 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 O81900 (/IMP) Q8S3F1 (/IMP)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
2 O49687 (/IMP) Q9FIP9 (/IMP)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
2 B9FXT3 (/IMP) Q9ZVX2 (/IMP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
2 Q39204 (/IEP) Q9ZPY8 (/IEP)
Anthocyanin-containing compound biosynthetic process GO:0009718
The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.
2 O49687 (/IMP) Q9FIP9 (/IMP)
Response to jasmonic acid GO:0009753
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.
2 Q39204 (/IMP) Q9FIP9 (/IMP)
Epidermal cell fate specification GO:0009957
The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
2 Q9CAD0 (/IMP) Q9FN69 (/IMP)
Response to chitin GO:0010200
A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus.
2 Q39204 (/IEP) Q9LTS4 (/IEP)
Positive regulation of anthocyanin biosynthetic process GO:0031542
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins.
2 Q9FN69 (/IMP) Q9FT81 (/IMP)
Response to freezing GO:0050826
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius.
2 Q9LPW3 (/IMP) Q9LSE2 (/IMP)
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
1 Q9FN69 (/IMP)
Endoplasmic reticulum organization GO:0007029
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
1 Q8S3F1 (/IMP)
Response to desiccation GO:0009269
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water.
1 Q39204 (/IEP)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
1 Q9LSE2 (/IEP)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
1 Q9ZVX2 (/IGI)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 Q39204 (/TAS)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 Q9LUK7 (/IEP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
1 Q39204 (/IEP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
1 Q9ZPY8 (/IMP)
Regulation of flavonoid biosynthetic process GO:0009962
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids.
1 Q9FT81 (/TAS)
Positive regulation of flavonoid biosynthetic process GO:0009963
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids.
1 Q39204 (/IEP)
Trichome branching GO:0010091
Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana.
1 Q9FN69 (/IMP)
Seed coat development GO:0010214
The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure.
1 Q9FT81 (/IMP)
Regulation of gibberellin biosynthetic process GO:0010371
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins.
1 Q9LSL1 (/IMP)
Stomatal lineage progression GO:0010440
The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex.
1 Q9LSE2 (/IMP)
Guard mother cell differentiation GO:0010444
The process in which a meristemoid acquires the specialized features of a guard mother cell.
1 Q9LPW3 (/IMP)
Hyperosmotic salinity response GO:0042538
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 Q9LUK7 (/IMP)
Regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619
Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q39204 (/IMP)
Gibberellin catabolic process GO:0045487
The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators.
1 Q9LSL1 (/IMP)
Seed development GO:0048316
The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves.
1 Q9FT81 (/IMP)
Anther development GO:0048653
The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure.
1 Q6YUS3 (/IMP)
Anther morphogenesis GO:0048654
The process in which the anatomical structures of the anther are generated and organized.
1 Q6YUS3 (/IMP)
Anther wall tapetum cell differentiation GO:0048657
The process in which a relatively unspecialized cell acquires specialized features of an anther cell wall tapetum cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature.
1 Q6YUS3 (/IMP)
Regulation of sequence-specific DNA binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q39204 (/IMP)
Regulation of proanthocyanidin biosynthetic process GO:2000029
Any process that modulates the frequency, rate or extent of proanthocyanidin biosynthetic process.
1 Q9FT81 (/IEP)
Regulation of defense response to insect GO:2000068
Any process that modulates the frequency, rate or extent of defense response to insect.
1 Q39204 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
22 Q2QLR0 (/IC) Q2R3F6 (/IC) Q336P5 (/IC) Q336V8 (/IC) Q53L62 (/IC) Q5SMX2 (/IC) Q5SMX4 (/IC) Q657A4 (/IC) Q69IU0 (/IC) Q6YUS3 (/IC)
(12 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
16 B9FXT3 (/IDA) O23090 (/IDA) O23487 (/IDA) O49687 (/IDA) O81900 (/IDA) Q39204 (/IDA) Q6YUS3 (/IDA) Q9CAD0 (/IDA) Q9FIP9 (/IDA) Q9FN69 (/IDA)
(6 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O23090 (/IDA) Q9LNJ5 (/IDA)
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