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CATH Superfamily 3.90.190.20

Mur ligase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Mur ligase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4890: UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate ligase. [EC: 6.3.2.45]
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioate.
  • The enzyme catalyzes the reincorporation into peptidoglycan of the tripeptide L-alanyl-gamma-D-glutamyl-2,6-meso-diaminoheptanedioate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division.
  • The enzyme can also use the tetrapeptide L-alanyl-gamma-D-glutamyl- meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanyl-D-alanine in vivo and in vitro.
 20 A0A072ZF78 A0A086C0H8 A0A0E1ASH2 A0A0F6UA32 A0A0H2ZLZ2 A0A0H3QYX9 A0A0P1D7C8 A0A0V3TW26 A0A157TUF0 A0A1C7BLG3
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