The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Mur ligase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11084: UDP-N-acetylmuramate--L-alanine ligase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UDP-N-acetylmuramate--L-alanine ligase. [EC: 6.3.2.8]
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP- N-acetyl-alpha-D-muramoyl-L-alanine.
  • Involved in the synthesis of a cell-wall peptide.
1567 A0A010ZAT6 A0A015KZA4 A0A017RSZ8 A0A017T0J3 A0A023X2U4 A0A037Z097 A0A037Z5M6 A0A068MW11 A0A069AXD2 A0A069DLF9
(1557 more...)
D-alanine--D-alanine ligase. [EC: 6.3.2.4]
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.
  • Involved with EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8, EC 6.3.2.9 and EC 6.3.2.10 in the synthesis of a cell-wall peptide.
20 A0A0K1FJT0 A0A0X8K9M9 A0A1B1I297 A0A1B3X2K8 A0A1G1LWC6 A0A1G1NKI8 C4V3X9 D4S4Z2 E0NZ51 E4LK42
(10 more...)
UDP-N-acetylmuramate dehydrogenase. [EC: 1.3.1.98]
UDP-N-acetyl-alpha-D-muramate + NADP(+) = UDP-N-acetyl-3- O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.
  • NADH can to a lesser extent replace NADPH.
  • Formerly EC 1.1.1.158.
10 A0A059WNT1 A0A059WS14 A0A059WTU0 A0A059X015 A0A1G1JJC8 A0A1G1NKP8 A0A1G1NSU0 A0A1G1PEL3 A0A1G1PKW2 A0A1H2HAB6
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