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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 634734: Vesicle-fusing ATPase 1

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Vesicle-fusing ATPase. [EC: 3.6.4.6]
ATP + H(2)O = ADP + phosphate.
  • A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments.
  • They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily.
  • They include peroxin, which apparently is involved in Zellweger's syndrome.
 78 A0A023B2G5 A0A074T250 A0A077THB0 A0A077X8L4 A0A086JFW2 A0A086JVM6 A0A086KGM4 A0A086LKG2 A0A086PRD5 A0A086PUP8
(68 more...)
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 7 A0A0B4LH53 A3GI18 A8I175 C1DZA0 M9PH10 P46461 P54351
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 2 A0A0L1HWA5 A0A0P4U5P2
Phosphoribosylformylglycinamidine cyclo-ligase. [EC: 6.3.3.1]
ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.
    		 1 A0A0V0VWN6
    Acetyl-CoA carboxylase. [EC: 6.4.1.2]
    ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
    • Also catalyzes transcarboxylation; the plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA.
    		 1 A0A075AZS0
    Phosphoribosylglycinamide formyltransferase. [EC: 2.1.2.2]
    10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
      		 1 A0A0V0VWN6
      Phosphoribosylamine--glycine ligase. [EC: 6.3.4.13]
      ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)- (5-phospho-D-ribosyl)glycinamide.
      • Formerly EC 6.3.1.3.
      		 1 A0A0V0VWN6
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