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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 633728: Tyrosine-protein kinase (Capsular polysaccharide b...

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific protein-tyrosine kinase. [EC: 2.7.10.2]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain.
  • In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families.
  • Formerly EC 2.7.1.112.
 1813 A0A011QU98 A0A011RN54 A0A013SAL9 A0A014N794 A0A023CCT2 A0A023NQH6 A0A023VDU0 A0A023WRJ5 A0A023WU91 A0A023Y3V2
(1803 more...)
Receptor protein-tyrosine kinase. [EC: 2.7.10.1]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans.
  • In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
  • Formerly EC 2.7.1.112.
 180 A0A013SAL9 A0A024KY51 A0A029PJG0 A0A062A239 A0A063XHQ3 A0A069BAV0 A0A070CQ44 A0A070F2S9 A0A081Q1Y0 A0A081Q9T1
(170 more...)
Transferred entry: 2.7.10.1 and 2.7.10.2. [EC: 2.7.1.112]
    		75 A0A0D6V372 A0A0F6LBV9 A0A0H3HGW4 A5M4L1 B1HB10 B2ILP5 C1CBD1 C1CCB9 C9XVY2 M5JVD8
    (65 more...)
    Phosphatidylinositol-4,5-bisphosphate 4-phosphatase. [EC: 3.1.3.78]
    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 5-phosphate + phosphate.
    • Two pathways exist in mammalian cells to degrade 1-phosphatidyl- 1D-myo-inositol 4,5-bisphosphate (PtdIns(4,5)P(2)).
    • One is catalyzed by this enzyme and the other by EC 3.1.3.36, where the product is PtdIns4P.
    • The enzyme from human is specific for PtdIns(4,5)P(2) as substrate, as it cannot use PtdIns(3,4,5)P(3), PtdIns(3,4)P(2), PtdIns(3,5)P(2), PtdIns5P, PtdIns4P or PtdIns3P.
    • In humans, the enzyme is localized to late endosomal/lysosomal membranes.
    • It can control nuclear levels of PtdIns5P and thereby control p53- dependent apoptosis.
    • Formerly EC 3.1.3.n3.
    		 1 U2EGN2
    Phosphatidylserine decarboxylase. [EC: 4.1.1.65]
    Phosphatidyl-L-serine = phosphatidylethanolamine + CO(2).
      		 1 A0A160N1T4
      UDP-glucose 6-dehydrogenase. [EC: 1.1.1.22]
      UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
      • Also acts on UDP-2-deoxyglucose.
      		 1 A4WZY3
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