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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 633599: ATP-dependent RNA helicase MAK5

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
RNA helicase. [EC: 3.6.4.13]
ATP + H(2)O = ADP + phosphate.
  • RNA helicases utilize the energy from ATP hydrolysis to unwind RNA.
  • Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity.
  • Some helicases unwind DNA as well as RNA.
  • May be identical with EC 3.6.4.12 (DNA helicase).
 7 A0A178VI73 A2XVF7 A3AVH5 O74393 P0CQ90 P0CQ91 Q93Y39
Sterol 24-C-methyltransferase. [EC: 2.1.1.41]
S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
  • Acts on a range of sterols with a 24(25)-double bond in the side chain.
  • While zymosterol is the preferred substrate it also acts on desmosterol, 5-alpha-cholesta-7,24-dien-3-beta-ol, 5-alpha-cholesta- 5,7,24-trien-3-beta-ol, 4-alpha-methylzymosterol and others.
  • S-adenosyl-L-methionine attacks the Si face of the 24(25) double bond and the C-24 hydrogen is transferred to C-25 on the Re face of the double bond.
 2 A0A0B7FNV0 L8WZT0
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