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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 633377: Adenylate kinase isoenzyme 1

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UMP/CMP kinase. [EC: 2.7.4.14]
(1) ATP + (d)CMP = ADP + (d)CDP. (2) ATP + UMP = ADP + UDP.
  • This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.
  • dCMP can also act as acceptor.
  • Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase.
  • This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.
  • dCMP can also act as acceptor.
  • Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22.
  • Formerly EC 2.7.4.5.
 1159 A0A010RVQ5 A0A015JZH1 A0A016TQQ8 A0A016TRJ2 A0A016TSK3 A0A017S8J6 A0A022QAM8 A0A022RIQ9 A0A022RQP0 A0A022VW12
(1149 more...)
Adenylate kinase. [EC: 2.7.4.3]
ATP + AMP = 2 ADP.
  • Inorganic triphosphate can also act as donor.
 774 A0A016TYW3 A0A016TYW3 A0A016TZJ6 A0A016TZJ6 A0A016TZJ6 A0A016TZJ6 A0A016TZJ6 A0A016TZK0 A0A016TZK0 A0A016TZN6
(764 more...)
Nucleoside-diphosphate kinase. [EC: 2.7.4.6]
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
  • Many nucleoside diphosphates can act as acceptors.
  • Many ribo- and deoxyribonucleoside triphosphates can act as donors.
 178 A0A060VN21 A0A060WHG7 A0A060XBB9 A0A087XZB3 A0A087XZU7 A0A087YF80 A0A096M6B5 A0A096MDB8 A0A096N312 A0A0A0AHR4
(168 more...)
Nucleoside-triphosphate--adenylate kinase. [EC: 2.7.4.10]
NTP + AMP = NDP + ADP.
  • Many nucleoside triphosphates can act as donors.
 3 B0EEP6 B9R9Q5 B9S6Y7
Histone-lysine N-methyltransferase. [EC: 2.1.1.43]
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
    		 2 A0BJ67 A0DZ39
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