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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 633269: Vesicle-fusing ATPase 1

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Vesicle-fusing ATPase. [EC: 3.6.4.6]
ATP + H(2)O = ADP + phosphate.
  • A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments.
  • They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily.
  • They include peroxin, which apparently is involved in Zellweger's syndrome.
 26 A0A0B2PDE1 A0A0B2PQN3 A0A0B4LH53 A0A0B7FR54 A0A151UAB9 A0A178UTB9 B8MAR9 B9RZA0 E0VAZ4 E0VAZ5
(16 more...)
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 6 A0A0B4LH53 A3GI18 A8I175 M9PH10 P46461 P54351
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 1 A0A0L1HWA5
Phosphoribosylformylglycinamidine cyclo-ligase. [EC: 6.3.3.1]
ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.
    		 1 A0A0V0VWN6
    Acetyl-CoA carboxylase. [EC: 6.4.1.2]
    ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
    • Also catalyzes transcarboxylation; the plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA.
    		 1 A0A075AZS0
    Phosphoribosylglycinamide formyltransferase. [EC: 2.1.2.2]
    10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
      		 1 A0A0V0VWN6
      Phosphoribosylamine--glycine ligase. [EC: 6.3.4.13]
      ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)- (5-phospho-D-ribosyl)glycinamide.
      • Formerly EC 6.3.1.3.
      		 1 A0A0V0VWN6
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