The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 632764: ATP-dependent DNA helicase PIF1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 24 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA helicase activity GO:0003678
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
|
2 | P38766 (/ISS) Q54Z42 (/ISS) |
Single-stranded DNA-dependent ATP-dependent DNA helicase activity GO:0017116
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix.
|
2 | Q9H611 (/IDA) Q9UUA2 (/IDA) |
ATP-dependent 5'-3' DNA helicase activity GO:0043141
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'.
|
2 | Q9H611 (/IDA) Q9UUA2 (/IDA) |
G-quadruplex DNA binding GO:0051880
Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.
|
2 | P07271 (/IDA) Q9UUA2 (/IDA) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | Q9H611 (/IDA) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | Q80SX8 (/ISO) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q9UUA2 (/IC) |
DNA helicase activity GO:0003678
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
|
1 | P07271 (/IDA) |
DNA helicase activity GO:0003678
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
|
1 | P38766 (/IMP) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
1 | P07271 (/IDA) |
ATP-dependent DNA helicase activity GO:0004003
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
1 | P38766 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q80SX8 (/IPI) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q9H611 (/IDA) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q80SX8 (/ISO) |
Telomerase inhibitor activity GO:0010521
Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
|
1 | P07271 (/IDA) |
Telomerase inhibitor activity GO:0010521
Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
|
1 | P07271 (/IMP) |
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
1 | Q9UUA2 (/IDA) |
Single-stranded DNA-dependent ATP-dependent DNA helicase activity GO:0017116
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix.
|
1 | Q80SX8 (/ISO) |
ATP-dependent 5'-3' DNA/RNA helicase activity GO:0033682
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 5' to 3'.
|
1 | Q9H611 (/IDA) |
ATP-dependent 5'-3' DNA/RNA helicase activity GO:0033682
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 5' to 3'.
|
1 | Q80SX8 (/ISO) |
Telomeric DNA binding GO:0042162
Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.
|
1 | Q9H611 (/IDA) |
Telomeric DNA binding GO:0042162
Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.
|
1 | Q80SX8 (/ISO) |
ATP-dependent 5'-3' DNA helicase activity GO:0043141
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'.
|
1 | Q80SX8 (/ISO) |
Single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity GO:1990518
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'.
|
1 | Q9UUA2 (/IC) |
There are 30 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
G-quadruplex DNA unwinding GO:0044806
The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'.
|
3 | P07271 (/IMP) P38766 (/IMP) Q9UUA2 (/IMP) |
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
|
2 | P07271 (/IDA) Q9H611 (/IDA) |
Replication fork reversal GO:0071932
Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved.
|
2 | P07271 (/IGI) P38766 (/IGI) |
Mitochondrial genome maintenance GO:0000002
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
|
1 | P38766 (/IGI) |
Mitochondrial genome maintenance GO:0000002
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
|
1 | P07271 (/IMP) |
Telomere maintenance via recombination GO:0000722
Any recombinational process that contributes to the maintenance of proper telomeric length.
|
1 | P07271 (/IGI) |
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
|
1 | P07271 (/IMP) |
Double-strand break repair via break-induced replication GO:0000727
The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.
|
1 | P07271 (/IMP) |
DNA strand renaturation GO:0000733
The identification and annealing of complementary base pairs in single-strand DNA.
|
1 | P07271 (/IDA) |
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
1 | P38766 (/IGI) |
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
1 | P38766 (/IMP) |
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
1 | P38766 (/IPI) |
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
|
1 | P07271 (/IMP) |
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
|
1 | Q9UUA2 (/ISO) |
Replication fork processing GO:0031297
The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.
|
1 | Q9UUA2 (/EXP) |
Regulation of telomere maintenance GO:0032204
Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
|
1 | Q9H611 (/IDA) |
Regulation of telomere maintenance GO:0032204
Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
|
1 | Q80SX8 (/ISO) |
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
|
1 | P07271 (/IMP) |
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
|
1 | Q80SX8 (/ISO) |
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
|
1 | Q9UUA2 (/IDA) |
Mitochondrial DNA repair GO:0043504
The process of restoring mitochondrial DNA after damage.
|
1 | Q9UUA2 (/IMP) |
G-quadruplex DNA unwinding GO:0044806
The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'.
|
1 | Q9UUA2 (/IDA) |
Chromosome organization GO:0051276
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
|
1 | P07271 (/IMP) |
Chromosome organization GO:0051276
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
|
1 | Q54Z42 (/ISS) |
Negative regulation of telomerase activity GO:0051974
Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
1 | Q9H611 (/IDA) |
Negative regulation of telomerase activity GO:0051974
Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
1 | Q80SX8 (/ISO) |
Replication fork progression beyond termination site GO:0097046
Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks.
|
1 | P38766 (/IMP) |
DNA strand elongation involved in mitotic DNA replication GO:1902983
Any DNA strand elongation involved in mitotic cell cycle DNA replication.
|
1 | Q9UUA2 (/IMP) |
Removal of RNA primer involved in mitotic DNA replication GO:1903469
Any DNA replication, removal of RNA primer that is involved in mitotic cell cycle DNA replication.
|
1 | Q9UUA2 (/IGI) |
Positive regulation of G-quadruplex DNA unwinding GO:1905467
Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA unwinding.
|
1 | Q9UUA2 (/IMP) |
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q80SX8 (/IDA) Q9UUA2 (/IDA) |
Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
2 | P07271 (/IDA) P38766 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P07271 (/IDA) Q9UUA2 (/IDA) |
Nuclear replication fork GO:0043596
The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
2 | P07271 (/IDA) P38766 (/IDA) |
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
|
1 | Q9H611 (/IDA) |
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
|
1 | Q80SX8 (/ISO) |
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | Q9UUA2 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P07271 (/IC) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q80SX8 (/IMP) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q54Z42 (/ISS) |
Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
1 | P38766 (/IMP) |
Nuclear telomeric heterochromatin GO:0005724
Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus.
|
1 | Q9UUA2 (/IDA) |
Nuclear telomeric heterochromatin GO:0005724
Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus.
|
1 | P38766 (/IPI) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | Q9UUA2 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q80SX8 (/IMP) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q54Z42 (/ISS) |
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
|
1 | P07271 (/IDA) |
Site of double-strand break GO:0035861
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
|
1 | Q9UUA2 (/IDA) |
Nuclear replisome GO:0043601
A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
|
1 | Q9UUA2 (/EXP) |
Nuclear rDNA heterochromatin GO:1902377
Any rDNA heterochromatin that is part of a nucleus.
|
1 | Q9UUA2 (/IDA) |