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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 632705: ABC transporter ATP-binding protein

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Xenobiotic-transporting ATPase. [EC: 3.6.3.44]
ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
  • Enzymes of Gram-positive bacteria and eukaryotic cells that export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally.
  • Several distinct enzymes may be present in a single eukaryotic cell.
  • Many of them transport glutathione conjugates with drugs.
  • Some also show some 'flippase' (EC 3.6.3.1) activity.
  • Formerly EC 3.6.3.45.
 19 F2JYM1 F4CQI5 F4KXD1 F6GGY4 G4I5I3 K9PKV6 K9PT45 K9QH58 K9QHC0 K9UY59
(9 more...)
Peptide-transporting ATPase. [EC: 3.6.3.43]
ATP + H(2)O + peptide(In) = ADP + phosphate + peptide(Out).
  • A family of enzymes that exports alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria.
 12 A0A098FXX1 A0A1M4M7U8 B9NW87 F2JY31 F6AA84 F6CVZ2 G0ATY0 G7LSE2 Q312C9 V3TLV3
(2 more...)
Beta-glucan-transporting ATPase. [EC: 3.6.3.42]
ATP + H(2)O + beta-glucan(In) = ADP + phosphate + beta-glucan(Out).
  • An enzyme found in Gram-negative bacteria that exports beta-glucan.
 9 A0A174NFI1 A0A174P046 A0A174P8Z3 A0A174PA60 A0A174R539 A0A174Y4G2 A0A1C5U388 A0A1C6FC12 A0A1C6JUI7
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 8 A0A085G3L0 A0A085HAL5 A0A085HMR9 A0A1B7HLC4 A0A1B7I1X4 A0A1B7IH75 A0A1B7IKP9 A0A1B7JSY1
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 8 A0A085G3L0 A0A085HAL5 A0A085HMR9 A0A1B7HLC4 A0A1B7I1X4 A0A1B7IH75 A0A1B7IKP9 A0A1B7JSY1
Sulfate-transporting ATPase. [EC: 3.6.3.25]
ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In).
  • A bacterial enzyme that imports sulfate and thiosulfate anions.
 3 A0A0P1C148 B2J2H2 Q3MAZ4
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