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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 631955: Replication factor C subunit 2

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA-directed DNA polymerase. [EC: 2.7.7.7]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
  • Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • Cannot initiate a chain de novo.
  • Requires a primer which may be DNA or RNA.
  • See also EC 2.7.7.49.
 14 A0A074T5P5 A0A086JEX6 A0A086PGS1 A0A0D2KX20 A0A125YWJ7 A0A125YWJ9 A3GID9 B0EV71 B6AAJ5 B9RC55
(4 more...)
Glutamate N-acetyltransferase. [EC: 2.3.1.35]
N(2)-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L- glutamate.
  • Also has some hydrolytic activity on acetyl-L-ornithine, but the rate is 1% of that of transferase activity.
 4 A0A136J8H6 A0A1J7JIY8 G0SGJ3 M7SJ62
Amino-acid N-acetyltransferase. [EC: 2.3.1.1]
Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.
  • Also acts with L-aspartate and, more slowly, with some other amino acids.
 4 A0A136J8H6 A0A1J7JIY8 G0SGJ3 M7SJ62
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 2 A0A0L1HXW7 A0A0P4UF26
Acid phosphatase. [EC: 3.1.3.2]
A phosphate monoester + H(2)O = an alcohol + phosphate.
  • Wide specificity.
  • Also catalyzes transphosphorylations.
 1 A0A060T9W1
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