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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 631809: AAA ATPase family protein

There are 10 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA-directed DNA polymerase. [EC: 2.7.7.7]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
  • Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • Cannot initiate a chain de novo.
  • Requires a primer which may be DNA or RNA.
  • See also EC 2.7.7.49.
 45 A0A074SNU2 A0A085FJ51 A0A086JAC5 A0A086KPU3 A0A086Q9A6 A0A0A8TNL4 A0A0B7FSF4 A0A0D5YDM8 A0A0G9FBY6 A0A0H3EC21
(35 more...)
DNA helicase. [EC: 3.6.4.12]
ATP + H(2)O = ADP + phosphate.
  • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
  • Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15).
  • Some helicases unwind DNA as well as RNA (4,9).
  • May be identical with EC 3.6.4.13 (RNA helicase).
 39 A0A076JHD9 A0A076JJ87 A0A080N333 A0A086ZHX9 A0A086ZJ42 A0A086ZML2 A0A087A9Q2 A0A087ADK0 A0A087AHV7 A0A087APT6
(29 more...)
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 33 A0A060T9B1 A0A085AG02 A0A085GGR3 A0A085GJD9 A0A085GV17 A0A085H3G2 A0A085HLV9 A0A085HRQ1 A0A085JC18 A0A085U9U6
(23 more...)
Endopeptidase La. [EC: 3.4.21.53]
Hydrolysis of proteins in presence of ATP.
  • ATP hydrolysis is linked with peptide bond hydrolysis.
  • Vanadate inhibits both reactions.
  • A similar enzyme occurs in animal mitochondria.
  • Belongs to peptidase family S16.
 9 A0A076JHD9 A0A087DML5 A0A173Y1R4 A0A173ZAD5 A0A173ZZH6 A1A0Y3 A7A4Z0 D2Q9G9 R5GU57
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 4 A0A073KLU6 F9YTP0 G8Q8Q2 Q75JU2
Formyltetrahydrofolate deformylase. [EC: 3.5.1.10]
10-formyltetrahydrofolate + H(2)O = formate + tetrahydrofolate.
    		 4 A0A0E1SKW4 A0A0H3PED1 A4MV32 A4NZI7
    3-phosphoshikimate 1-carboxyvinyltransferase. [EC: 2.5.1.19]
    Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O- (1-carboxyvinyl)-3-phosphoshikimate.
      		 3 A0A0Y7K2F7 A0A0Y7K9K6 A0A0Y7MVP0
      Microtubule-severing ATPase. [EC: 3.6.4.3]
      ATP + H(2)O = ADP + phosphate.
      • Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
      		 1 B0EGY1
      Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
      ATP + a protein = ADP + a phosphoprotein.
      • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
      • Formerly EC 2.7.1.37 and EC 2.7.1.70.
      		 1 A0A1J1IT77
      Serine--tRNA ligase. [EC: 6.1.1.11]
      (1) ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). (2) ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
      • This enzyme also recognizes tRNA(Sec), the special tRNA for selenocysteine, and catalyzes the formation of L-seryl-tRNA(Sec), the substrate for EC 2.9.1.1.
      		 1 A8T5G9
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