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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 631696: Ribosome-associated GTPase EngA

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UMP/CMP kinase. [EC: 2.7.4.14]
(1) ATP + (d)CMP = ADP + (d)CDP. (2) ATP + UMP = ADP + UDP.
  • This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.
  • dCMP can also act as acceptor.
  • Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase.
  • This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.
  • dCMP can also act as acceptor.
  • Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22.
  • Formerly EC 2.7.4.5.
 74 A0A022L0C3 A0A069SYM7 A0A072N933 A0A076JGX4 A0A083WY81 A0A083XP37 A0A083XWX8 A0A088QHE6 A0A095WX86 A0A095YAW2
(64 more...)
(d)CMP kinase. [EC: 2.7.4.25]
ATP + (d)CMP = ADP + (d)CDP.
  • The prokaryotic cytidine monophosphate kinase specifically phosphorylates CMP (or dCMP), using ATP as the preferred phosphoryl donor.
  • Unlike EC 2.7.4.14, a eukaryotic enzyme that phosphorylates UMP and CMP with similar efficiency, the prokaryotic enzyme phosphorylates UMP with very low rates, and this function is catalyzed in prokaryotes by EC 2.7.4.22.
  • The enzyme phosphorylates dCMP nearly as well as it does CMP.
 38 A0A076JI84 A0A080N5Z0 A0A086Z0G3 A0A086ZJ69 A0A086ZRP8 A0A086ZTC5 A0A087A194 A0A087AEG9 A0A087AS88 A0A087AW13
(28 more...)
Pantoate--beta-alanine ligase (AMP-forming). [EC: 6.3.2.1]
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
    		 8 A0A072N933 A0A076JGX4 A0A0G9M8C9 A0A139B7Q2 A7A5Q8 C0BTK2 D2QAF8 R5H6Y5
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