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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 631655: ATP-binding cassette, sub-family D

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 22 A0A060T0V4 A0A0P4U536 A0A171B745 B3MQL9 B3MZ72 B3NWD7 B3P9V3 B4GUZ5 B4L1S7 B4L791
(12 more...)
Xenobiotic-transporting ATPase. [EC: 3.6.3.44]
ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
  • Enzymes of Gram-positive bacteria and eukaryotic cells that export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally.
  • Several distinct enzymes may be present in a single eukaryotic cell.
  • Many of them transport glutathione conjugates with drugs.
  • Some also show some 'flippase' (EC 3.6.3.1) activity.
  • Formerly EC 3.6.3.45.
 18 A0A074TUF4 A0A086JZR7 A0A086KZP3 A0A086LHV6 A0A086MBF1 A0A086QBJ6 A0A125YLZ5 A0A139XMR8 B7PGT9 B9RKV1
(8 more...)
Heme-transporting ATPase. [EC: 3.6.3.41]
ATP + H(2)O + heme(In) = ADP + phosphate + heme(Out).
  • An enzyme found in Gram-negative bacteria that exports heme.
 13 A0A073CEB3 A0A073CHI1 A0A073CKY7 A0A1J1KZK3 A9B9C7 B2J689 B2J694 B2J9J9 B7SMU1 C8TEL3
(3 more...)
Histone-lysine N-methyltransferase. [EC: 2.1.1.43]
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
    		 5 A0A0D3EL49 A0A0D9Y589 A0A0E0FII6 A0A0E0MT53 B9EU42
    Fatty-acyl-CoA-transporting ATPase. [EC: 3.6.3.47]
    ATP + H(2)O + fatty acyl CoA(Cis) = ADP + phosphate + fatty acyl CoA(Trans).
    • An animal and Saccharomyces cerevisiae enzyme that transports fatty acyl CoA into and out of peroxisomes.
    		 2 Q94FB9 Q94FB9
    Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
    NTP + H(2)O = NDP + phosphate.
    • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
    • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
    • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
    		 1 A0A171B745
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