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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 631516: Elongation factor 4

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Elongation factor 4. [EC: 3.6.5.n1]
GTP + H(2)O = GDP + phosphate.
  • The enzyme is required for accurate and efficient protein synthesis under certain stress conditions.
  • May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.
  • Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.
  • Binds to ribosomes in a GTP-dependent manner.
 655 A0A014L4A4 A0A014NQY1 A0A023CMA3 A0A023D9R8 A0A023PAC3 A0A037UPM7 A0A059MYX7 A0A059XWJ8 A0A059Y402 A0A060PYR5
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